I-30: Human Endometrial Receptivity:from The Basic Research to Clinical Translation
نویسنده
چکیده مقاله:
The endometrium is a hormonally regulated organ that is non-adhesive to embryos throughout most of the menstrual cycle in humans. Endometrial receptivity refers to a hormone-limited period in which the endometrial tissue acquires a functional and transient ovarian steroid-dependent status allowing blastocyst adhesion. Functional genomic studies of human endometrium in natural cycles have demonstrated that endometrial receptivity is an active process involving up- and down-regulation of hundreds of genes, for review see. Personalized medicine is a well-accepted concept in reproductive medicine except for the endometrial factor that is still neglected. Our group has developed the endometrial receptivity array (ERA), a customized array of 238 genes coupled to a computational predictor capable of diagnosing a functionally receptive endometrium regardless of its histological appearance. The accuracy of the diagnostic tool ERA has been demonstrated to be superior to endometrial histology and results are completely reproducible 29 to 40 months later. Clinical results obtained will be presented to demonstrate the diagnostic and therapeutic efficiency of the ERA test in patients with implantation failure (IF), through personalization of the day of embryo transfer (pET). As well in our laboratory we are involved in new noninvasive diagnostic methods using endometrial fluid (EF). The aim of our new study is to use lipidomics to unravel the specific composition of EF through menstrual cycle, identify lipid biomarkers for endometrial receptivity and to demonstrate their clinical diagnostic value. Our results open the assessment of PGE2 and PGF2, as the basis of a non-invasive diagnostic method to be performed 24 hours prior to embryo transfer, to diagnose the endometrial receptive status.
منابع مشابه
The Curious Road from Basic Pathogen Research to Clinical Translation
I was very lucky to have stumbled into curiosity-driven scientific research for a career, because I suspect that I have always had a poorly developed herd instinct. In my case, when I set up my first research lab as a new primary investigator in 1980, I elected to study a family of viruses that infect only rabbits. Why rabbits, you ask? I had become fascinated by events that had happened a half...
متن کاملPART I. BASIC RESEARCH Introduction to Basic Research
Since Stephen Paget’s “seed-and-soil” theory was published in 1889, a wealth of research has focused on the cascade of events involved in the spread of cancer cells from the primary tumor to secondary organs. As Paget highlighted, in addition to the intrinsic properties of metastatic cancer cells, features of the microenvironment in target organs of metastasis are also critical for successful t...
متن کاملNew trends in pain research: from basic research to clinical translation.
The small town of Parghelia on the Tyrrhenian coast (Calabria, Italy) recently provided an attractive setting for a two-year-awaited international meeting on “NEW TRENDS IN PAIN RESEARCH: From Basic Research to Clinical Translation” (13-15 September, 2012). The event, attended by around sixty participants, brought together young researchers, PhD students, international scientists and academics ...
متن کاملHuman Locomotion in Hypogravity: From Basic Research to Clinical Applications
We have considerable knowledge about the mechanisms underlying compensation of Earth gravity during locomotion, a knowledge obtained from physiological, biomechanical, modeling, developmental, comparative, and paleoanthropological studies. By contrast, we know much less about locomotion and movement in general under sustained hypogravity. This lack of information poses a serious problem for hum...
متن کاملCytokine-induced killer (CIK) cells: from basic research to clinical translation.
The accumulation of basic researches and clinical studies related to cytokine-induced killer (CIK) cells has confirmed their safety and feasibility in treating malignant diseases. This review summarizes the available published literature related to the biological characteristics and clinical applications of CIK cells in recent years. A number of clinical trials with CIK cells have been implemen...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 8 شماره 2.5
صفحات 12- 12
تاریخ انتشار 2014-07-01
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023